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Clinical Endocannabinoid Deficiency Theory

Researchers believe that the underlying cause of many ailments, particularly those related to the immune system and inflammation, could be a disorder referred to as clinical endocannabinoid deficiency.

Endocannabinoid deficiency is a theory for the symptoms and conditions that develop when the body’s endocannabinoid system isn’t functioning properly. We’ve previously discussed the endocannabinoid system and its role in regulating a wide array of body processes to maintain our health. The body naturally produces neuromodulatory lipids called endocannabinoids, which interact cannabinoid receptors throughout the body to elicit chemical responses that keep the body in balance.

​The theory of clinical endocannabinoid deficiency suggests that in some cases the body doesn’t produce enough endocannabinoids or enough receptors for the endocannabinoid system to function properly. As a result, the many functions aren’t regulated properly and the body becomes unbalanced, allowing diseases to arise.

Cannabinoid researcher Dr. Ethan Russo first proposed the theory of clinical endocannabinoid deficiency in 2004. In a study, published in Neuro Endocrinology Letters, Russo suggested that deficient cannabinoid levels might explain why some conditions develop. Russo had examined the available literature and found evidence that people diagnosed with certain conditions had lower levels of endocannabinoids. He suggested that a person being deficient in endocannabinoids and/or cannabinoid receptors could explain why supplementing with cannabinoids found in plants like hemp were proving effective at alleviating some conditions.

“Migraine, fibromyalgia, [irritable bowel syndrome] and related conditions display common clinical, biochemical and pathophysiological patterns that suggests an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines,” Russo concluded in his research review.

Cannabinoids found in plants like hemp, including cannabidiol (CBD), are analogous to the endocannabinoids naturally produced by the body. Research shows that they interact with the cannabinoid receptors of the endocannabinoid system to elicit chemical responses that help bring balance to the body.
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A deficiency in endocannabinoids has been linked to several other disorders besides migraine, fibromyalgia and irritable bowel syndrome. The endocannabinoid system is responsible for regulating the release of neurotransmitter, so diseases that are attributed to their dysfunction, such as Alzheimer’s disease and Parkinson’s disease, may be related to clinical endocannabinoid deficiency.


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​Void Where Prohibited by Law.

Hemp is defined by Section 10111 of the US Farm Bill: The term ‘hemp’ means the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis.”

CBD Nutritional only sells products that meet the Federal definition of industrial hemp (Dried hemp and hemp products containing less than .3% Delta 9 THC).
Legal Disclaimer: The CBD (Cannabidiol) contained in CBD Nutritional products has been grown, processed and produced in accordance to the 2014 Farm Bill, Section 7606. This product is legal for marketing in the United States pursuant to Sec. 7606. The Food and Drug Administration (FDA) considers non-THC based hemp products to be "food based" and therefore legal without a medical marijuana license.  CBD Nutritional does not sell or distribute any products that are in violation of the United States Controlled Substances Act (US.CSA).

Our products are not intended to diagnose, treat, prevent, or cure any disease. Due to restrictions and limitations we are not making any medical claims whatsoever. As a user you acknowledge that the information contained within this website is not intended to be nor is to be treated as a substitute for professional medical advice relative to a specific medical conditions. As with all supplements it is important to let your doctor know what you are taking. ​

These statements have not been evaluated by The Food and Drug Administration. Our website and CBD products are not intended to diagnose, treat, cure or prevent any disease. Under no circumstances does our website CBD Nutritional imply that any and all products and formulas are meant to diagnose, treat, cure or prevent any diseases.



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