The two most common forms of extracted CBD found in stores are full-spectrum (whole-plant extract) and pure CBD isolate. Isolated CBD is different from full-spectrum CBD extract in that it only contains CBD and none of the other cannabinoids, terpenes, or healthy fatty acids that commonly result from the whole-plant extraction process.
Cannabis, with its complex chemical structure, contains over 100 active cannabinoids aside from CBD. It also contains terpenes, which have anti-inflammatory properties, and are regarded as increasing the efficacy of cannabinoids. Although they are not rated as important as CBD when it comes medical benefits, some of these other cannabinoids have been found to have symptom alleviating qualities as well. The cannabinoids CBN and CBG for example, are found in most full-spectrum extracts and studies have shown that both contain anti-inflammatory, anti-bacterial, and pain relieving properties.
Whole-plant extracts typically contain a carefully measured amount of the cannabis plant's most prominent cannabinoid, THC, although usually not in a large enough amount to have any psychological effects. When present together, CBD and its cannabinoid colleagues, as well as terpenes, produce what is known as an entourage effect. The synergistic relationship between cannabinoids and terpenes has been shown to increase the healing properties of each.
A study published by the Lautenberg Center for Immunology and Cancer Research, which aimed its focus on the effectiveness of CBD isolate compared to full-plant extract, supported this concept, stating in its summary that "in all of the tests, the isolated CBD was ineffective both before and after a certain dosage, while the effectiveness of the full-spectrum solution continued to increase as higher doses were administered. The results all indicate that CBD is only effective against swelling and pain at a certain dose, and that cannabis solutions containing a full range of cannabinoids will continue to provide corresponding effects as the dosage is increased."
Given the results of this study, it would seem to confirm that full-spectrum extract is preferable over CBD isolate for most CBD users, but CBD isolate is still frequently used and believed by some to be more effective than full-plant extract. This belief is led by the idea that CBD is the only medically sought after cannabinoid in the cannabis plant, aside from THC. Many CBD isolate users are under the impression that by consuming only the CBD cannabinoid and no terpenes or any other "unnecessary" components of the plant, they are getting a more powerful or effective dose of CBD. The lack of entourage effect means the benefits are reduced when compared to full-spectrum CBD consumption.
However, CBD isolate does have something to offer CBD users that full-spectrum extracts does not. The fact that full-spectrum extracts invariably contain low levels of THC means that some users prefer to play it safe and stick to pure CBD by itself, out of fear of failing a drug test or experiencing a form of "high", although both of these occurrences have been found to be fairly unlikely.
THC is one of the cannabinoids involved in the "entourage effect" stated earlier so it is ideal for inclusion in CBD supplementation. A recent article on full-spectrum CBD demonstrates the importance of THC inclusion by stating, "In hemp THC is a minor constituent and appears only in trace amounts under 0.3% by dry weight, as required by the U.S. government for hemp products. THC mimics the action of anandamide, a neurotransmitter naturally produced in the human body, and binds to CB1 receptors in the endocannabinoid system found mostly in the brain. The extremely low levels of THC in hemp make hemp oil non-psychoactive and safe for all ages to use."
Companies who extract CBD are realising that cannabis has more to offer medicinally than just CBD or THC, and that there is little to no reason to not include all that this "super-plant" has to offer in the extraction process.
This all serves to underline the importance of testing CBD extract for the various levels of active ingredients. As more scientific literature emerges supporting the entourage effect, and increased benefits of full-spectrum CBD compared to CBD isolate, we can expect the manufacture and sale of CBD goods based around isolate to greatly reduce in the coming years.
Currently there is a massive body of evidence supporting the fact that the chemical compound discovered in the cannabis plant called cannabidiol (CBD) can be a natural alternative to treating chronic pain and reducing menopausal symptoms due to its rich therapeutic properties. This is because, like many NSAIDs, CBD and CBDA, the raw form of CBD, is a COX-2 enzyme inhibitor, and can also potentially help beat the anxiety associated with pain.
As menopause has been found to disrupt the regular performance of the body’s endocannabinoid system, which regulates our mood, fertility and reproduction, pain, and other bodily functions, cannabinoids are being studied for their interaction within the Endocannabinoid system, which maintains balance/homeostasis of our body. Currently there is much information on the following menopausal symptoms that CBD can help with.
Aches & Joint Pain
Without estrogen, our bodies produce higher levels of inflammatory molecules (specifically, tumor necrosis factor, or TNFα). This means arthritis symptoms could skyrocket during menopause. More than 60% of women aged 40 to 64 suffer from pain in their muscles and joints. Cannabidiol has proven anti-inflammatory properties. In mice, CBD is anti-arthritic, protects joints against inflammatory damage, and lowers levels of inflammatory TNFα. Low-impact exercise and dietary changes are also excellent resources in a fight against inflammation.
Sleep is one of life's most rejuvenating therapies. With menopause many women find it difficult to have a relaxing night’s rest, triggering fatigue, anxiety, and other health issues. A significant case study on a person with post-traumatic stress disorder (PTSD) in 2016 revealed that the CBD oil was capable of alleviating sleep disruptions and anxiety. Naturally CBD is effective menopausal insomnia as well.
CBD does stabilize blood pressure and ease muscles, allowing one to get a betters night sleep.
CBD has also been documented to aid people in gaining a considerable amount of energy to help them to get through the day. Its anxiety-inhibiting and relaxing effects make sleep improvement achievable for insomniac women. However, it must also be stated that high doses of CBD may also have more “energizing” or “up” effects for some people. For many, a combination of small amounts of THC and myrcene may also be helpful.
It’s tempting to blame memory loss on age, but even younger women who go through surgical menopause can experience rapid memory loss. The brain region responsible for memory, learning and emotion, the hippocampus, is a hotbed of synaptic plasticity. Hormones like estrogen and progesterone encourage neurons in the hippocampus to form new connections, and our memories might suffer without these hormones.
Scientists are actively investigating CBD for encouraging synaptic plasticity and neuroprotection, particularly in the hippocampus. However, there is not yet solid evidence for its recommendation, and there are many other ways you can protect this important brain region. If you want to improve your memory consider the following;
1) Exercise, exercise promotes neuron growth by boosting your brain’s brain-derived neurotrophic factor (BDNF) levels. BDNF is a protein that encourages the growth of new neurons and connections (synapses). 2) Spend time with others--social isolation harms both our bodies and our brains. living in social isolation produce less BDNF in their hippocampi. Social isolation can even negate the power of exercise
3) Restorative sleep--both reduced hours or disrupted sleep — can impair neurogenesis.
4) Sex is great for growing new neurons.
5) Alcohol might not “kill” brain cells, but it does shrink your hippocampus. In rats, moderate drinking (equivalent to 3-4 drinks per day) reduced neurogenesis in the hippocampus by 40%. However, rats also have a burst of regeneration after 7 days of sobriety. So, if you drink regularly, try incorporating sober weeks into your schedule.
6) Meditation. Long-term meditators have larger hippocampi, and a 3-month retreat program of yoga and meditation raises BDNF levels.
7) Healthy diet. Although there is no perfect diet for everyone, it appears that high-fat diets, particularly when combined with refined sugars, are bad for neurogenesis. Vitamin deficiencies can also get in the way of hippocampal regeneration.
8) Intermittent fasting. Studies show that fasting and caloric restriction could benefit your brain. In rats, fasting increases levels of interferon‐γ — a molecule that protects the hippocampus from stress-induced death. And in mice, fasting increased BDNF and neural growth. Fasting isn’t for everyone, but your digestive tract might at least appreciate an occasional break.
9) Supplements. Although CBD oil research is the most promising, studies show that curcumin, resveratrol, omega-3 fatty acids, green tea, quercetin (a plant flavonoid) and bilobalide (from ginkgo biloba) supplements could all contribute to stimulating regeneration of the hippocampus.
Bone density loss
We’ve all heard about the importance of dietary calcium and exercise for preventing osteoporosis, but new research suggests that inflammation from arthritis or other conditions might be one of the biggest causes of bone resorption. Inflammatory TNFα is particularly adept at telling your body to increase bone resorption.
How CBD could help: The same anti-inflammatory features that make CBD oil a popular remedy for arthritic symptoms might also prove useful for bone health. In rats with periodontitis, CBD lowers TNFα levels and prevents oral bone loss. Some research has found that CBD interacts with a cannabinoid receptor that may play a role in bone density loss. CBD may, therefore, be able to reduce the rate of bone density loss that can occur during menopause. Resistance exercise also decreases TNFα levels, which may explain why exercise can help prevent bone loss. A low bone density can increase the chance of fractures or bruises, so it is an important symptom to treat.
Menopausal Weight Gain
Hormones shape our bodies on so many levels, including controlling our metabolism. Without estrogen, our bodies burn fewer calories — even while sleeping — and we also burn less fat during exercise. Even if you cut calories and maintain a stable weight throughout menopause, the ongoing hormonal shift tells your body to trade in lean muscle mass for abdominal fat. And this pattern of fat storage unfortunately raises your predisposition to insulin resistance, diabetes and cardiovascular disease.
Population studies have found that adults who use cannabis products have lower insulin levels and smaller waist circumferences. Cannabidiol could contribute by switching on genes for healthy metabolism (through the PPAR-γ receptor). CBD also helps buffer the activity of natural endocannabinoids,including 2-AG, which is linked to insulin resistance and ramped up during menopause.
Less estrogen, sometimes mean more abdominal fat and weight gain in menopausal women. A 2016 study discovered how CBD triggers the proteins and genes that participate in increasing fat breakdown and how it intensifies the body’s ability to burn calories.
Also, cannabinoids like CBD has been validated to help regulate food cravings. CBD was found to aid in lowering insulin levels and improving metabolism, reducing the probability of diabetes and heart disease for menopausal women.
Anxiety/Stress, Mood Swings and Depression
Many women experience menopausal anxiety, depression, and a few episodes of panic attacks due to their fluctuating hormone levels. Estrogen and progesterone influence the activity of serotonin and other neurotransmitters in the brain — which directly affect mood. As levels of these hormones become erratic and eventually plummet, your neurochemistry will change. CBD is efficient in lowering stress and improving one’s mood. Extensive studies prove CBD’s anxiolytic capabilities for the treatment of anxiety disorder and depression. Although CBD cannot cure depression and/or anxiety, there is evidence that show how it can improve the symptoms associated with such mental health problems.
Hot Flashes & Night Sweats
Hot flashes and night sweats disrupt our sleep and daily routines, which can reduce the quality of our lives. These “vasomotor” symptoms are caused by altered neurochemistry in the hypothalamus — your body’s thermostat control. In other words, your body’s cooling system — blood vessel dilation & sweat response — gets switched on way too easily. When tested in the lab, women who suffer from hot flashes are triggered when their body temperatures increase by only 1.5 degrees, whereas other women’s bodies don’t switch on the cooling system unless their temperatures increase almost 3 degrees.
Because hot flashes have a neurochemical basis, some SSRIs and antidepressants can help relieve hot flashes. Although there aren’t studies that have specifically tested CBD for hot flashes, its influence on the body’s serotonin system could be one reason why some women swear by CBD for this symptom. Other treatments like therapy, hypnosis and relaxation techniques that calm the nervous system can also influence your neurochemistry and help reduce hot flashes.
Genitourinary syndrome of menopause (bladder control, vaginal atrophy & dryness)
Is a condition where the vaginal tissue becomes thinner, drier and more inflamed — affecting more than half of postmenopausal women. It can become painful to sit, walk, or urinate, with a higher risk for incontinence. without estrogen, vaginas become densely innervated with pain-perceiving nerves and other nerves that further cut off the blood flow.
Estrogen helps keep blood flowing to the pelvic region, delivering fresh oxygen to the tissues of the urinary tract and sexual organs — keeping things elastic and healthy. Once menopause arrives, women should give their pelvis some extra love and attention to keep up the blood flow.
Along with regular sexual activity, a topical lubricant that contains cannabinoids like CBD or THC — which are both potent vasodilators — can increase blood flow to the pelvic region. This keeps tissues healthy while also moisturizing the vaginal canal. Topical CBD can also fight inflammation, relax muscles and calm pain-perceiving nerves in the vulva and vagina, making CBD-infused lube and suppositories one of women’s best companions through menopause.
Another cannabinoid that will not get you high...with laser specific healing capacities. As with CBD, it is anti-inflammatory, a natural analgesic, antibacterial, anti-convulsive, a brain cell stimulant, antidepressant, anti-proliferative, aids with sleep and tends to increase appetite.
Look for full spectrum hemp extracts with a higher profile of CBG to treat:
Does CBG Have Any Side Effects?CBG does not have any side effects when taken in therapeutic doses. The key words there are “therapeutic doses.” You can experience negative side effects if you consume too much of any substance…even water.
Thankfully, CBG only becomes a problem when taken in excess of 300 milligrams per kilogram of body weight.
For a 180-pound person, that means they would have to consume 54,000 milligrams of CBG for it to become dangerous. To put that in perspective, a 180-pound person suffering from severe pain should take, at the most, 25 milligrams to feel relief.
If you are part of the 80% of Americans who say they have trouble getting to sleep at least weekly, you may want to try CBD as a sleep aid. Instead of getting a prescription for potentially dangerous or addictive prescription drugs, try using this natural supplement known to help many users with sleeping. Cannabidiol is found in both cannabis and hemp. The compound does not have any psychoactive effects and, instead, is used by many to cope with pain and other health issues.
Common Sleep Disorders
Many people are affected by sleep disorders. One of the most common disorders is insomnia, which refers to difficulty falling asleep and staying asleep. Insomnia can be caused by physical or mental reasons, and even by lifestyle reasons such as an inconsistent work schedule. Sleepwalking and sleep terrors are other disorders that can affect sleep, and both have a wide range of causes. Sleepwalking refers to physically moving through your house while asleep, and sleep terrors are characterized by screaming and short, violent bursts of terror that differ from nightmares. The benefits of CBD for sleep disorders are mostly linked to the calming effects of CBD. CBD can reduce anxiety and pain for many users, two major sleep deterrents.
CBD as a Restful Sleep Supplement
One of CBDâs appeals is how many ways there are to take the supplement. From edible candies to oils and tinctures, there are appealing options for everyone. In one survey, 60% of users reported taking CBD to help with sleep. Some studies suggest that cannabinoids can help regulate the sleep cycle. The CBD Therapy strain is designed specifically to help with difficulties sleeping since this is one of the most common uses for the CBD compound. To find the right dosage, start off with a standard dose, and adjust as needed according to the effects you experience. Studies suggest a a high dose is beneficial for getting the full effects as a sleep aid.
When To Take CBD for Sleep
The best time to take CBD oil to help with sleep is typically between 30 minutes to an hour before bedtime. Putting drops under the tongue is one of the fastest ways to get the effects of CBD, so this is a good choice for administering the oil. If you would prefer a slower release of the compound, the drops can also be mixed into food. Pre-measured capsules are another ingestion method, but these are slower to take effect, so should be taken hours before you plan to sleep.
After reading this industry article, click here, I began thinking what I would like to see the FDA do for our CBD industry. My wish list has to do with labeling, as I hear about other products, being cheaper, not working at all or only a little, and I see CBD bottles people bring to our store. So here goes...1)Many do not contain labels that clearly say what is in the bottle. I'm talking about what is the CBD form, is it Full Spectrum, Isolate, Distillate or Blend? 2)Next, many bottles do not say how many milligrams of CBD is contained in bottle. I've even seen in the number of servings, errors that do not calculate correctly with the total number of milligrams in the bottle! 3)Thirdly, country of origin needs be stated. I'd personally like to know the State, because lets face it some USA States have a multitude of toxic environmental concerns. 4)None of the bottles I have examined contain a traceable batch number. Every one of our CBD Nutritional Hemp Extracts has always had a batch number, so one may download the 3rd party lab analysis results from this website. Click Here
5)And number 5 if the product is a Hemp Blend, I would like to see the % or milligrams of each type of Hemp product, ie; Full Spectrum, Isolate, Distillate. I don't like that companies are able to put as little as 1 drop of a Full Spectrum Hemp product and call it Full Spectrum, when it contains 99%+ isolate. And worse they charge a true Full Spectrum price for an isolate hemp product, which is a much cheaper hemp product. Of course I could go on and on, but I'll step off the soap box for now.