Research points toward cannabinoids having an adaptive, immunomodulating effect, rather than just suppressing immune activity.
Some studies suggest that cannabinoids like THC and CBD are immunosuppressant, which can explain the relief experienced by medical cannabis users with autoimmune diseases and chronic inflammation.
It gets even more complicated when we consider that the effects of cannabis are mediated primarily by the endocannabinoid system, which scientists believe interacts with all biological activity, including our immune system.
Endocannabinoids are produced on demand, travelling backwards across chemical synapses and modulating cell activity. This partly explains why the ECS has been termed a homeostatic regulator – continually working to maintain a state of biological balance.
The ECS regulates a plethora of physiological processes, including immune function and inflammation. Both CB1 and CB2 receptors can be found on immune cells, although there are between 10-100 times more CB2 receptors than CB1. Endocannabinoids act upon immune cells directly through the CB2 receptor.
CB2 receptor activation creates an anti-inflammatory effect and is therefore a therapeutic target for autoimmune disorders and neurodegenerative disease.1 However, any ECS immunosuppressant activity is thought to be transient, and can be overridden when necessary in the presence of infection.2
CANNABIS AND THE IMMUNE SYSTEMWhen we talk about cannabis, we’re dealing with upwards of 400 different molecules. These include the more frequently studied cannabinoids like THC and CBD, more than 100 other minor cannabinoids, dozens of terpenes, and a host of flavonoids – the combination of which varies according to the cannabis strain.
CBD, despite little binding affinity with cannabinoid receptors, is also considered to be immunosuppressant, reducing cytokine production3 and inhibiting T-cell function4.
But that’s only part of the story. A new wave of research and mounting anecdotal evidence points towards cannabinoids having an adaptive, immunomodulating effect, rather than just suppressing immune activity.
1. Caroline Turcotte, Marie-Renée Blanchet, Michel Laviolette, and Nicolas Flamand. The CB2 receptor and its role as a regulator of inflammation. Cellular and Molecular Life Sciences. 2016; 73(23): 4449–4470. doi: 10.1007/s00018-016-2300-4
2. Rupal Pandey, Khalida Mousawy, Mitzi Nagarkatti, and Prakash Nagarkatti. Endocannabinoids and immune regulation. Pharmacol Res. 2009 Aug; 60(2): 85–92, doi: 10.1016/j.phrs.2009.03.019
Interestingly how people will follow others who are socially known rather than family members or even best friends who recommend something. I want for everyone to feel comfortable with your decision to try CBD, so I am including this list of Hollywood celebs who are endorsing CBD to entice you a little more.;-)
One potential way to make quitting easier and more fun is by switching to pre-made hemp-ettes that are rich in cannabidiol (CBD), marijuana’s secondary active ingredient. In a small 2013 study, CBD users cut cigarette intake by 40%.
CBD comes from the cannabis plant, but it doesn’t make you feel high like pot’s main active ingredient, THC. Instead, studies indicate CBD can reduce social anxiety, inflammation, and create a calm feeling without much euphoria.
CBD is also empowering plenty of smokers to step down from highly addictive and carcinogenic tobacco. The World Health Organization concludes CBD is not habit-forming. And NIDA-funded research failed to find an association between cannabis smoking and lung disease or cancer. These CBD-rich hemp-ettes help people quit by offering a similar experience for when intense cravings hit, such as during social occasions, right after sex, or other times when you might habitually light up a cigarette.
A 2019 review of early clinical studies finds that “animal and human studies suggest that [CBD has] the potential to reduce craving and relapse in abstinent substance users, by impairing reconsolidation of drug-reward memory, salience of drug cues, and inhibiting the reward-facilitating effect of drugs.”
A 2018 double-blind, placebo-controlled study of a mega-dose of CBD (800 mg) for tobacco cessation found that it helped quitters pay less attention to tobacco around them. That is, CBD “reduced salience and pleasantness of cigarette cues”, but didn’t lessen cravings or withdrawal.
Federal cannabis prohibition stymies further research. But we are hearing good things from clients utilizing Hemp-ettes to comfortably reduce and eliminate tobacco cigarettes.
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CBG has been found to act on very specific physiological systems and problems, and results for medicinal use are promising:
One of the most popular methods of administering cannabidiol is through CBD edibles. It is a simple and easy way to get your ideal dosage, and there are so many options. CBD is a compound found in hemp that does not have the same psychoactive effects as THC. Since it is not a marijuana product, no medical marijuana card is required. Many users find it helpful as a method of treating pain, anxiety, and more.
Take CBD Through Candies
If you have a sweet tooth, these CBD edibles are sure to catch your eye. The packaging on all candy options clearly lists the amount of CBD in milligrams per piece so that you can keep close track of your dosage with each delicious bite. The choices include sour gummy bears with 10 mg per piece and caramels with 15 mg per piece. If you are shopping for friends and loved ones, consider buying them gift cards so they can choose their favorite candy or other methods of using CBD.
Beverages Infused with CBD
These exciting options are perfect for those who love to curl up with a cup of tea at the end of a long day. We offer three varieties of CBD infused tea in packages of 1.5 oz that make approximately 12 cups. Passion Green is fruity and refreshing, while the Golden Chai option is spiced and soothing. Raspberry Daze is a rooibos with a fruity tinge. If tea isn’t your usual drink, try the CBD Nano Water. The bottled water measures CBD in nanograms, which allows for better, more thorough absorption.
Lozenges, Oils, and Capsules
These options are a convenient, no-nonsense method of ingesting CBD. Lozenges come in 50 mg strength and dissolve in the mouth to provide more instant relief. CBD capsules come in a range of strengths, with 15 mg, 25 mg, and 50 mg capsules available. They can be taken the same way as other supplements, which makes them easy to work into a daily routine. The oil options are very concentrated and are taken sublingually. The droppers offer precision doses, which should be held beneath the tongue for a minute to allow for maximum absorption. These ingestibles are efficient and especially helpful if you know your ideal dose.
The CBD Store AZ has been providing reliable methods of CBD usage for more than five years. With options ranging from nasal sprays to edibles, you are sure to find one that appeals to you. We offer classes on CBD use and administration for up to six people at a time, so new users can learn about the benefits of CBD and how to find the best dosage for the desired effects.