One of the most popular methods of administering cannabidiol is through CBD edibles. It is a simple and easy way to get your ideal dosage, and there are so many options. CBD is a compound found in hemp that does not have the same psychoactive effects as THC. Since it is not a marijuana product, no medical marijuana card is required. Many users find it helpful as a method of treating pain, anxiety, and more.

Take CBD Through Candies
If you have a sweet tooth, these CBD edibles are sure to catch your eye. The packaging on all candy options clearly lists the amount of CBD in milligrams per piece so that you can keep close track of your dosage with each delicious bite. The choices include sour gummy bears with 10 mg per piece and caramels with 15 mg per piece. If you are shopping for friends and loved ones, consider buying them gift cards so they can choose their favorite candy or other methods of using CBD.

Beverages Infused with CBD
These exciting options are perfect for those who love to curl up with a cup of tea at the end of a long day. We offer three varieties of CBD infused tea in packages of 1.5 oz that make approximately 12 cups. Passion Green is fruity and refreshing, while the Golden Chai option is spiced and soothing. Raspberry Daze is a rooibos with a fruity tinge. If tea isn’t your usual drink, try the CBD Nano Water. The bottled water measures CBD in nanograms, which allows for better, more thorough absorption.

Lozenges, Oils, and Capsules
These options are a convenient, no-nonsense method of ingesting CBD. Lozenges come in 50 mg strength and dissolve in the mouth to provide more instant relief. CBD capsules come in a range of strengths, with 15 mg, 25 mg, and 50 mg capsules available. They can be taken the same way as other supplements, which makes them easy to work into a daily routine. The oil options are very concentrated and are taken sublingually. The droppers offer precision doses, which should be held beneath the tongue for a minute to allow for maximum absorption. These ingestibles are efficient and especially helpful if you know your ideal dose.

The CBD Store AZ has been providing reliable methods of CBD usage for more than five years. With options ranging from nasal sprays to edibles, you are sure to find one that appeals to you. We offer classes on CBD use and administration for up to six people at a time, so new users can learn about the benefits of CBD and how to find the best dosage for the desired effects.

The very best part of being involved with CBD is how many people we help with their discomforts.  It truly is such an amazing feeling, when a client returns, usually bringing friends, and with a sparkle in their eye--thanking you for saving their life.  Recently our staff at the store assisted a woman who has had migraines her entire life.  She was skeptical, but desperate and so she left with her CBD products after learning how CBD may be beneficial for her.  She returned a week later, with friend, and exclaimed that Yoshi, our wonderful CBD expert, saved her life.  With tears in her eyes, she explained that she has not had a migraine in a week and how she has had migraines her entire life on a weekly basis.  She was so appreciative and excited about life that it made me feel blessed for this truly amazing compound.  I have seen the results from many who suffer from migraines, but she touched my heart with her sharing of her life long struggle and how we were able to assist.  Her story left me more determined to reach those suffering.  Clinical studies and scientific research are rare, but I dug up the following to help people with their decision to try CBD for migraines.  

What Does the Research Actually Say?

The common thread you can find throughout the existing scientific research on this subject is that CBD oil can improve some migraine symptoms for most people.

In 2016, Pharmacotherapy published a study showing how the frequency of migraine headaches dropped from 10.4 headaches a month to 4.6 in a group of 121 medical marijuana users.

Cannabis and Cannabinoid Research published a review last year showing a clear history of cannabinoid use in the treatment and reduction of migraines.

Uses and Safety Previous research studies have shown that CBD oil, unlike THC, does not cause a euphoric high or psychotropic effects, and is typically less controversial and safer for medicinal use. CBD oil has been shown, in a limited number of studies, to be effective in the treatment of many disorders, including diabetes, arthritis, multiple sclerosis, and migraines. 

A recent study discovered that the type of cannabis that CBD is composed of is very well tolerated and safe in humans. The researchers who conducted the study reported that when the type of cannabis with THC was given to study subjects, there was an increased heart rate, anxiety, and psychotic symptoms noted; but, when CBD oil—lacking THC—was given, there were no side effects (including psychotic symptoms).

ConclusionsWhile there is a lot of good to say about the use of CBD oil as a migraine treatment, there simply is not enough evidence to say conclusively that it will be 100% effective 100% of the time for 100% of the population.
Perhaps, in time, laws will change and more research can be done to develop CBD oil as a reliable migraine treatment, but we are simply not there yet.
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What the evidence does show, however, is that CBD oil can absolutely help relieve some symptoms related to migraines.

“Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective”, states the study’s abstract. “Cannabidiol (CBD) has shown promising results in painful conditions.” With this in mind, researchers “aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms.”

For the study, “Wistar adult male diabetic rats were treated acutely or sub-chronically (for 14 days) with CBD (0.1, 0.3 or 3 mg/Kg, intraperitoneal; i.p.) and had their mechanical threshold assessed using the electronic Von Frey. ” Acute treatment with CBD (at doses of 0.3 and 3 mg/Kg) “exerted a significant anti-allodynic effect, which is not associated with locomotor impairment. “The antinociceptive effect of CBD (3 mg/Kg) was not altered by the pre-treatment with CB1 or CB2 receptor antagonists (AM251 and AM630; respectively; both at a dose of 1 mg/kg, i.p.) nor by glycine receptor antagonist (strychnine hydrochloride, 10 μg/rat, intrathecal, i.t.).”

“However,”  the study states, “this effect was completely prevented by the pre-treatment with the selective 5-HT1A receptor antagonist WAY 100135 (3 μg/rat, i.t.). Sub-chronic treatment with CBD (0.3 or 3 mg/Kg) induced a sustained attenuation of the mechanical allodynia in DBT rats.”

DBT rats “presented significantly lower spinal cord levels of serotonin, which was prevented by the daily treatment with CBD (0.3 mg/Kg).”

Taken together, the data “suggest that CBD may be effective in the treatment of painful diabetic neuropathy and this effect seems to be potentially mediated by the serotonergic system activation through 5-HT1A receptors.”

The full abstract can be found below:

Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms. Wistar adult male diabetic rats were treated acutely or sub-chronically (for 14 days) with CBD (0.1, 0.3 or 3 mg/Kg, intraperitoneal; i.p.) and had their mechanical threshold assessed using the electronic Von Frey. Acute treatment with CBD (at doses of 0.3 and 3 mg/Kg) exerted a significant anti-allodynic effect, which is not associated with locomotor impairment. The antinociceptive effect of CBD (3 mg/Kg) was not altered by the pre-treatment with CB1 or CB2 receptor antagonists (AM251 and AM630; respectively; both at a dose of 1 mg/kg, i.p.) nor by glycine receptor antagonist (strychnine hydrochloride, 10 μg/rat, intrathecal, i.t.). However, this effect was completely prevented by the pre-treatment with the selective 5-HT1A receptor antagonist WAY 100135 (3 μg/rat, i.t.). Sub-chronic treatment with CBD (0.3 or 3 mg/Kg) induced a sustained attenuation of the mechanical allodynia in DBT rats. DBT rats presented significantly lower spinal cord levels of serotonin, which was prevented by the daily treatment with CBD (0.3 mg/Kg). Taken together, our data suggest that CBD may be effective in the treatment of painful diabetic neuropathy and this effect seems to be potentially mediated by the serotonergic system activation through 5-HT1A receptors.
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This abstract, and a link to the full text, can be found on the National Institute of Health’s website at the following link: https://www.ncbi.nlm.nih.gov/pubmed/30898678

As one in more than a hundred chemical components in the hemp plant, CBD is having its well-deserved spotlight moment within the discussion of cannabis and wellness due to it anti-inflammatory, pain relieving, and calming effects. However, there’s more information known about another element of the plant besides cannabinoids — terpenes. Today, we cover the basics of terpenes, how they interact with the body, and their applications in plant-based wellness routines.

Terpenes are organic compounds that play an important role in the aromas, flavors, and natural defenses of many plants. Over 20,000 are known to exist, and cannabis has been determined to have over 100. They are the reason fruits and flowers have distinctive, unique smells, and evolved to attract pollinators and provide plants a means of defense. More than simply flavor and aroma, cannabis-derived terpenes can also affect the intensity and duration of certain effects of cannabinoids.

Cultivating terpenes in cannabis depends on light, humidity, temperature, and even the methods of processing plants. Strains can be adjusted to produce more or less of certain terpenes in order to tweak the effect terpenes have on the body’s endocannabinoid system, contributing to feelings of alertness, relaxation, or a specific symptom relief.

Terpenes interact with the human body’s robust endocannabinoid system and work together with cannabinoids to potentially enhance their therapeutic benefits. They can have distinct, varying characteristics, like being particularly energizing or sedating, so understanding their role is crucial in identifying appropriate products for your lifestyle.
Specific terpenes can be controlled and adjusted for in products containing CBD, to highlight various effects or enhance flavor profiles, and their ongoing study is crucial to the understanding of their application in wellness. Many in the CBD space are looking to terpene research as one of the key directions the industry is heading.

Some commonly found terpenes:

Myrcene: Also found in mangoes and basil, myrcene is often used for sleep, but it also lowers the “blood-to-brain barrier,” meaning faster onset of active ingredients. It can be very abundant naturally, or controlled for in cultivation. It’s also commonly used for pain relief.

Linalool: This terpene is also found in lavender and has shown incredible anti-inflammatory and calming properties, as well as having a promising anti-epileptic effect.

Pinene: Pinene is one of the most common terpenes and can be found in cannabis, pine needles, rosemary, and parsley, and its potential effects include memory retention, anxiety treatment, and inflammation. 

Limonene: With a distinct citrusy fragrance, limonene is a natural mood elevator and stress reliever, with antifungal properties. It is particularly effective in topicals because it enhances cannabinoid absorption through the skin.

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Finally, I have some documentation to share with you about the efficacy of cannabis for migraines.  We see it and hear from our clients almost daily about the "life changing" results of consuming CBD.  One of those is headaches, specifically migraines.  

A study from the University of Colorado, published in Parmacotherapy, showed that the frequency of migraines in patients who used cannabis dropped from 10.4 per month to 4.6—a number that’s both statistically and clinically significant.  The study’s senior author, Professor Laura Borgelt, said “There was a substantial improvement for patients in their ability to function and feel better.”  Borgelt and her team reached their conclusion after reviewing the medical charts of 121 patients collected over a four-year period. A large majority of subjects experienced some reduction in headaches: 85 percent reported a decrease, while 12 percent had no change, and only a small, but unfortunate 2.5 percent experienced more migraines.   

While this is good news, the study only looked at the effects of cannabis on migraine and not the biochemistry of how it achieves them. “We believe serotonin plays a role in migraine headaches, but we are still working to discover the exact role of cannabinoids in this condition,” Borgelt said.  

Secondary findings showed that different cannabis delivery routes had different strengths: Inhalation, is one of the quickest for onset, generally within 2 minutes was best for treating acute migraines. On the other hand, sublingual and edibles, which have a longer onset, helped prevent headaches.